Pharma Reaction System
Engineered with pharmaceutical applications in mind.
See it in action - fast heat-up, fast cool-down
The Pharma Reaction System features a compact design and is available in standardized capacities ranging from 16 to 63 L. For larger volumes, systems with a glass-lined vessel and a glass dome - allowing optimal observation of the process - can be realized up to 630 L.
Pharma Reaction System
Engineered for pharmaceutical applications with a compact, space-efficient design
QVF®-Pharma Reactor Highlights
Function
The QVF® Pharma Reactor is a modular reactor system specifically designed for reaction and distillation processes. The reaction stage operates under total reflux conditions, followed by a distillation step in which volatile solvents are efficiently removed.
The system offers high flexibility and can be operated under slight overpressure (up to 0.5 barg) as well as under vacuum conditions.
Materials of Construction.
The system utilizes high-performance materials to ensure reliability and chemical resistance:
- Borosilicate glass 3.3 – highly chemical-resistant and thermally stable
- Glass-lined steel – robust and corrosion-resistant
- PTFE (polytetrafluoroethylene) – inert and resistant to aggressive chemicals
This combination of materials makes the system ideally suited for pharmaceutical synthesis, chemical research, laboratory-scale reactions, pilot-scale processing, and GMP-compliant applications.
Concept
The glass-lined reaction vessel is designed for GMP-compliant pharmaceutical and chemical processing, offering excellent corrosion resistance, cleanability, and process safety. Key features include a block flange for GMP-compliant connection, heating jacket to the flange, minimal dead-space bottom outlet valve, and a fully welded stainless-steel insulation jacket with foam-glass insulation.
The white enamel interior ensures optimal visual inspection.
The distillation assembly complies with the Pressure Equipment Directive, and all glass components from DN25 carry CE marking. Product lines are installed at a 5° incline for complete drainage, and the inclined condenser features a cleaning nozzle. The receiver vessel can be emptied and rinsed during operation.
An integrated sampling valve enables safe sampling even under vacuum.
QVF® SUPRA flat flanges with fire-polished sealing surfaces and a precision gasket groove ensure minimal dead space and secure the positioning of the GMP gasket.
The basic version of the Pharma Reaction System features comprehensive instrumentation covering all essential functions: precise temperature monitoring of the vessel contents and distillate, as well as operating pressure indication via a tantalum diaphragm manometer. A rupture disc ensures reliable overpressure protection. The rotation speed of the glass-lined impeller agitator can be smoothly adjusted using the handwheel on the drive.
All instruments can be easily assigned to the correlating vessels.
Technical data
| Nominal reactor | l | 16 | 25 | 40 | 63 |
| Nominal reactor diameter | DN | 300 | 450 | 450 | 450 |
| Nominal heating area | m² | 0.25 | 0.37 | 0.53 | 0.75 |
| Condenser | m² | 1 | 1 | 2x0.7 | 2x1 |
| Distillate cooler | m² | 0.2 | 0.2 | 0.3 | 0.3 |
| Feed vessel | l | 5 | 10 | 20 | 20 |
| Distillate receiver | l | 2x5 | 2x10 | 2x20 | 2x20 |
Special benefits of our Pharma Reactor Range
The glass-lined reaction vessel developed by De Dietrich Gemany Mainz combines the following special features:
Compact version
Standardized volumes from 16 to 63 L in a space-saving compact version
Innovative Reactor
Maximum heat transfer with a heating jacket extending up to the flange
Clear Process Visibility
Optimal monitoring through a glass dome
GMP Compliance
Designed to meet GMP requirements
Self-Draining System
Engineered for complete and efficient drainage
Enhanced Visual Control
White enamel for improved visual control
Options
The basic Pharma Reaction System is modular and
can be upgraded with the following options:
- Hydraulic lifting device for the reaction vessel
- Phase separator
- Electronic speed indicator
- High pressure version
- Coated glass components
- Double-acting mechanical seal
- Anchor, turbine and propeller type stirrers
- Process Control
You have question?
Documents to download
Request a download
In order to process your brochure request efficiently, we kindly ask you to provide the required information through our form.